(1S,2R)-2-(4-Bromo-phenyl)-cyclopropylamine hydrochloride - Names and Identifiers
(1S,2R)-2-(4-Bromo-phenyl)-cyclopropylamine hydrochloride - Physico-chemical Properties
(1S,2R)-2-(4-Bromo-phenyl)-cyclopropylamine hydrochloride - Introduction
(1S,2R)-2-(4-Bromo-phenyl)-cyclopropylamine hydrochloride is an organic compound with the molecular formula C9H10BrClN and the common name is ((1S,2R)-2-(4-Bromo-phenyl)-cyclopropylamine hydrochloride). The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: White crystalline powder
-Melting point: About 140-142 ° C
-Solubility: Soluble in water and alcohol solvents, insoluble in non-polar solvents
Use:
- (1S,2R)-2-(4-Bromo-phenyl)-cyclohexylamine hydrochloride is an organic reagent, which is widely used in pharmaceutical synthesis, organic synthesis and chemical research.
-It can be used as a catalyst, ligand or intermediate to participate in asymmetric reactions, cyclization reactions and coupling reactions.
Method:
- (1S,2R)-2-(4-Bromo-phenyl)-cyclohexylamine hydrochloride can be synthesized by the following steps:
1. 2-Bromophenylsilane and cyclopropane -1-amine are reacted in the presence of a base to obtain 4-bromophenylcyclopropane -1-amine.
2. 4-Bromophenylcyclopropane -1-amine hydrochloride is reacted with triethyl phosphite to obtain trans-2-(4-bromophenyl) cyclopropane -1-amine.
3. Trans -2-(4-bromophenyl) cyclopropan-1-amine is reacted with hydrochloric acid to give (1S,2R)-2-(4-Bromo-phenyl)-cyclohexylamine hydrochloride.
Safety Information:
- (1S,2R)-2-(4-Bromo-phenyl)-cyclopropylamine hydrochloride is an organic compound that needs to be handled in a suitable laboratory environment with attention to personal protective measures.
-May cause irritation and damage to eyes, skin and respiratory tract, avoid direct contact.
-Should be stored in a dry, cool and away from flammable materials, and avoid contact with oxides and acids.
Please note that the preparation and use of chemical substances need to follow safe operating procedures and comply with relevant laws and regulations. When using this compound, please refer to specific experimental methods and relevant safety information.
Last Update：2024-04-09 15:18:04